Colour Online: See the article online to view Figs. 1–3 in colour.
Tumoral heterogeneity of hepatic cholangiocarcinomas revealed by MALDI imaging mass spectrometry
Article first published online: 1 APR 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: Tissue Proteomics and Imaging Mass Spectrometry
Volume 14, Issue 7-8, pages 965–972, April 2014
How to Cite
Le Faouder, J., Laouirem, S., Alexandrov, T., Ben-Harzallah, S., Léger, T., Albuquerque, M., Bedossa, P. and Paradis, V. (2014), Tumoral heterogeneity of hepatic cholangiocarcinomas revealed by MALDI imaging mass spectrometry. Proteomics, 14: 965–972. doi: 10.1002/pmic.201300463
- Issue published online: 1 APR 2014
- Article first published online: 1 APR 2014
- Accepted manuscript online: 12 FEB 2014 06:00AM EST
- Manuscript Accepted: 27 JAN 2014
- Manuscript Revised: 24 JAN 2014
- Manuscript Received: 24 OCT 2013
- Ligue contre le Cancer, Hauts-de-Seine, the PAIR-INCA on Liver Cancer, and European Union Seventh Framework Programme FP7. Grant Number: 305259
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
|pmic7689-sup-0001-TableS1.docx||48K||Table S1. Putative protein name of several discriminant peaks|
|pmic7689-sup-0002-TableS2.xlsx||46K||Table S2. Nano-LC-ESI-MS/MS of the tryptic digest resulted in the characterization of N-term acetylated TYB-4.|
|pmic7689-sup-0003-TableS3.xlsx||109K||Table S3. Nano-LC-ESI-MS/MS of the tryptic digest resulted in the characterization of Neutrophil defensin 1.|
|pmic7689-sup-0004-FigureS1.tif||2028K||Figure S1. Mean spectra of H-CC (red) and P-CC (green) representative of the two cohorts. Higher magnification spectra highlight 4 differential peaks, m/z 3442, 3371, 3485 corresponding to HNP 1–3 overexpressed in H-CC, and m/z 4965 corresponding to TYB-4 overexpressed in P-CC. a.u., arbitrary unit.|
|pmic7689-sup-0005-FigureS2.tif||1532K||Figure S2. Microscopic view of a peripheral cholangiocarcinoma (HE staining, magnification x100): Tumor is composed of glandular structures associated with fibrous stroma.|
|pmic7689-sup-0006-FigureS3.tif||1528K||Figure S3. Microscopic view of a hilar cholangiocarcinoma (HE staining, magnification x100): Tumor is made of glandular and massive carcinomatous proliferation associated with fibrous cellular stroma.|
|pmic7689-sup-0007-FigureS4.tif||109K||Figure S4. Average spectra of representative cases of (A) normal liver – NL, (B) cirrhosis – CIR, (C) hepatocellular carcinoma – HCC, (D) peripheral cholangiocarcinoma – P-CC and (E) hilar cholangiocarcinoma – H-CC. The red and green stars indicate HNP 1–3 and TYB-4, respectively.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.