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FilenameFormatSizeDescription
pmic7689-sup-0001-TableS1.docx48KTable S1. Putative protein name of several discriminant peaks
pmic7689-sup-0002-TableS2.xlsx46KTable S2. Nano-LC-ESI-MS/MS of the tryptic digest resulted in the characterization of N-term acetylated TYB-4.
pmic7689-sup-0003-TableS3.xlsx109KTable S3. Nano-LC-ESI-MS/MS of the tryptic digest resulted in the characterization of Neutrophil defensin 1.
pmic7689-sup-0004-FigureS1.tif2028KFigure S1. Mean spectra of H-CC (red) and P-CC (green) representative of the two cohorts. Higher magnification spectra highlight 4 differential peaks, m/z 3442, 3371, 3485 corresponding to HNP 1–3 overexpressed in H-CC, and m/z 4965 corresponding to TYB-4 overexpressed in P-CC. a.u., arbitrary unit.
pmic7689-sup-0005-FigureS2.tif1532KFigure S2. Microscopic view of a peripheral cholangiocarcinoma (HE staining, magnification x100): Tumor is composed of glandular structures associated with fibrous stroma.
pmic7689-sup-0006-FigureS3.tif1528KFigure S3. Microscopic view of a hilar cholangiocarcinoma (HE staining, magnification x100): Tumor is made of glandular and massive carcinomatous proliferation associated with fibrous cellular stroma.
pmic7689-sup-0007-FigureS4.tif109KFigure S4. Average spectra of representative cases of (A) normal liver – NL, (B) cirrhosis – CIR, (C) hepatocellular carcinoma – HCC, (D) peripheral cholangiocarcinoma – P-CC and (E) hilar cholangiocarcinoma – H-CC. The red and green stars indicate HNP 1–3 and TYB-4, respectively.

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