Article

Newly designed hydrogel with both sensitive thermoresponse and biodegradability

  1. Takatsune Yoshida1,
  2. Takao Aoyagi2,†,*,
  3. Etsuo Kokufuta1,
  4. Teruo Okano2

Article first published online: 23 JAN 2003

DOI: 10.1002/pola.10595

Issue

Journal of Polymer Science Part A: Polymer Chemistry

Journal of Polymer Science Part A: Polymer Chemistry

Volume 41, Issue 6, pages 779–787, 15 March 2003

Additional Information

How to Cite

Yoshida, T., Aoyagi, T., Kokufuta, E. and Okano, T. (2003), Newly designed hydrogel with both sensitive thermoresponse and biodegradability. Journal of Polymer Science Part A: Polymer Chemistry, 41: 779–787. doi: 10.1002/pola.10595

Author Information

  1. 1

    Institute of Applied Biochemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki-ken 305-8572, Japan

  2. 2

    Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan

  1. †

    Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890-0065, Japan

*Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan

Publication History

  1. Issue published online: 23 JAN 2003
  2. Article first published online: 23 JAN 2003
  3. Manuscript Accepted: 18 NOV 2002
  4. Manuscript Received: 22 JUL 2002

Funded by

  • Scientific Research on Priority Areas (A). Grant Number: 11167276
  • Ministry of Education, Science, Sport and Culture, Japan
  • Japan Society for the Promotion of Science. Grant Number: JSPS-RFTF96I00201

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Keywords:

  • poly(N-isopropylacrylamide);
  • hydrogels;
  • thermoresponsive polymer;
  • biodegradable;
  • poly(amino acids);
  • biodegradable;
  • hydrogel;
  • crosslinking;
  • drug delivery systems

Graphical Abstract

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The synthesis and characterization of a hydrogel based on N-isopropylacrylamide (IPAAm) crosslinked with biodegradable poly(amino acid) is described. The hydrogel showed a good thermoresponse and temperature-modulated biodegradation, therefore, it could be applied to an injectable matrix for drug controlled release.

Abstract

The synthesis and characterization of thermoresponsive hydrogels on the basis of N-isopropylacrylamide (IPAAm) copolymers crosslinked with biodegradable poly(amino acids) are described. This hydrogel was prepared with two kinds of reactive IPAAm-based copolymers containing poly(amino acids) as the side-chain groups and activated ester groups. We introduced the graft chains by decarboxylation polymerization of amino acid N-carboxyanhydrides initiated from lateral amino groups in the PIPAAm copolymer. The hydrogels easily crosslinked with degradable poly(amino acid) chains by only mixing the copolymer aqueous solutions. The gelling method in this study would provide some of the following innovative features: (1) no necessary removal of unreacted monomers and so forth, (2) simpler loading of drugs into the hydrogels (only mixing when gelling), and (3) easier insertion into the body. On the basis of the swelling ratio measurement of the hydrogel, large volume changes dependent on temperature changes were observed. Moreover, the enzymatic temperature-dependent degradation was confirmed. The results suggested that these hydrogels could be used for an injectable or implantable matrix of temperature-modulated drug release. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 779–787, 2003

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