New fluorinated oxazoline block copolymer lowers the adhesion of platelets on polyurethane surfaces
Article first published online: 10 MAR 2003
Copyright © 1994 John Wiley & Sons, Inc.
Journal of Polymer Science Part A: Polymer Chemistry
Volume 32, Issue 11, pages 2187–2192, August 1994
How to Cite
Kaku, M., Grimminger, L. C., Sogah, D. Y. and Haynie, S. I. (1994), New fluorinated oxazoline block copolymer lowers the adhesion of platelets on polyurethane surfaces. J. Polym. Sci. A Polym. Chem., 32: 2187–2192. doi: 10.1002/pola.1994.080321122
- Issue published online: 10 MAR 2003
- Article first published online: 10 MAR 2003
- Manuscript Accepted: 24 FEB 1994
- Manuscript Received: 9 JUL 1993
- poly (oxazoline);
We have prepared an amphiphilic oxazoline block copolymer of hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly[2-(2-perfluorooctyl)ethyl-2-oxazoline] chains. By controlling the length and composition of polymer chains, we found that this fluorinated block copolymer can be readily dissolved in water. Furthermore, we can achieve a stable surface coating of the fluorinated block copolymer by dissolving the copolymer in water, then coating the aqueous copolymer solution onto surfaces of nonwater-soluble polymers. This is a simple and useful method of modifying the surface character of polymer substrates. We have found that the polyether urethane (PEU) coated by block copolymer has a different surface chemistry and biological reactivity than the uncoated PEU. From XPS analysis, we found the fluorinated copolymer was coated on PEU (atomic % of F: 31.3 on coated PEU, 0.3 on uncoated). The two surfaces have different affinities for biological molecules. Specifically, the fibrinogen adsorption on the fluorinated copolymer-coated PEU was 62 ± 39 ng/cm2, compared to a value of 156 ± 99 ng/cm2 for uncoated PEU. In an ex vivo evaluation of platelet adhesion, the surface of coated PEU attached a few white cells while uncoated PEU was covered with activated platelets. © 1994 John Wiley & Sons, Inc.