Article

Automated parallel investigations/optimizations of the reversible addition-fragmentation chain transfer polymerization of methyl methacrylate

  1. Martin W. M. Fijten,
  2. Michael A. R. Meier,
  3. Richard Hoogenboom,
  4. Ulrich S. Schubert*

Article first published online: 6 OCT 2004

DOI: 10.1002/pola.20346

Issue

Journal of Polymer Science Part A: Polymer Chemistry

Journal of Polymer Science Part A: Polymer Chemistry

Volume 42, Issue 22, pages 5775–5783, 15 November 2004

Additional Information

How to Cite

Fijten, M. W. M., Meier, M. A. R., Hoogenboom, R. and Schubert, U. S. (2004), Automated parallel investigations/optimizations of the reversible addition-fragmentation chain transfer polymerization of methyl methacrylate. Journal of Polymer Science Part A: Polymer Chemistry, 42: 5775–5783. doi: 10.1002/pola.20346

Author Information

  1. Laboratory of Macromolecular Chemistry and Nanoscience (SMN), Eindhoven University of Technology and Dutch Polymer Institute (DPI), P.O. Box 513, 5600 MB Eindhoven, The Netherlands

*Laboratory of Macromolecular Chemistry and Nanoscience (SMN), Eindhoven University of Technology and Dutch Polymer Institute (DPI), P.O. Box 513, 5600 MB Eindhoven, The Netherlands

Publication History

  1. Issue published online: 6 OCT 2004
  2. Article first published online: 6 OCT 2004
  3. Manuscript Accepted: 11 JUN 2004
  4. Manuscript Received: 18 MAY 2004

Funded by

  • Dutch Polymer Institute (DPI)
  • Dutch Scientific Organization (NWO)

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Keywords:

  • reversible addition-fragmentation chain transfer polymerization;
  • methyl methacrylate;
  • combinatorial material research;
  • high-throughput experimentation;
  • automated MALDI TOFMS spotting;
  • parallel chemistry

Graphical Abstract

Thumbnail image of graphical abstract

Picture of the Chemspeed Accelerator™ automated synthesizer platform with four reactor blocks and the 4 needle head. Left top: reproducibility test of the methyl methacrylate polymerization monitored by GPC. Left bottom: chain extension experiments monitored by automated MALDI TOFMS and GPC.

Abstract

Poly(methyl methacrylate)s were successfully synthesized in a controlled fashion via reversible addition-fragmentation chain transfer polymerizations utilizing an automated synthesizer. Sixteen polymers were synthesized in a parallel way utilizing the Chemspeed Accelerator™ SLT100 to investigate the reproducibility and the control over the polymerizations. The obtained polymers were characterized by gel permeation chromatography (GPC) and automated MALDI TOFMS measurements, thereby proving the reproducibility and controllability of the investigated automated setup. Furthermore, temperature optimization reactions were performed utilizing an individually heatable reactor block. Moreover, to demonstrate the presence of active polymer chains in the reaction mixture, chain extension polymerizations were performed on the automated synthesizer. The results obtained from these chain extension experiments demonstrate the possibility to design well-defined A-b-B block copolymers with different monomers as building units. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 5775–5783, 2004

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