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AGET ATRP in water and inverse miniemulsion: A facile route for preparation of high-molecular-weight biocompatible brush-like polymers

Authors

  • Jung Kwon Oh,

    1. Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213
    Current affiliation:
    1. Dow Chemical Company, Midland, MI 48674
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  • Fabien Perineau,

    1. Laboratoire de Chimie des Polymères-UMR 7610, Université P. et M. Curie and CNRS, 4 Place Jussieu, 75252 Paris, Cedex 05, France
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  • Bernadette Charleux,

    1. Laboratoire de Chimie des Polymères-UMR 7610, Université P. et M. Curie and CNRS, 4 Place Jussieu, 75252 Paris, Cedex 05, France
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  • Krzysztof Matyjaszewski

    Corresponding author
    1. Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213
    • Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213
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Abstract

Activators generated by electron transfer for atom transfer radical polymerization (AGET ATRP) of oligo(ethylene glycol) monomethyl ether methacrylate (OEOMA) was investigated in homogeneous aqueous solution targeting DP = 1000, and in inverse miniemulsion targeting DP = 600, at 30 °C. Several reaction parameters were examined in the preparation of biocompatible, brush-like, high-molecular-weight, water-soluble polymers. They include concentration of ascorbic acid (AscA), ratio of water to OEOMA, mode of addition of AscA, and ratio of initiator to Cu(II) complex. The results obtained in these studies indicate that AGET ATRP retains all of the benefits of normal ATRP and, additionally, provides a facile route for the preparation of well-controlled high-molecular-weight polymers because of the use of oxidatively stable catalyst precursors. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 1771–1781, 2009

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