Modulated molecular recognition by a temperature-sensitive molecularly-imprinted polymer

Authors

  • Songjun Li,

    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211
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  • Srikanth Pilla,

    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211
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  • Shaoqin Gong

    Corresponding author
    1. Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211
    2. Department of Materials, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211
    • Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211
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Abstract

Modulated molecular recognition was achieved in a temperature-sensitive molecularly-imprinted polymer. Using PNIPA as the temperature-sensitive element, the adenine-imprinted polymer (i.e., MIP-S) was prepared and characterized. The MIP-S exhibited a temperature-responsive molecular recognition behavior because of the thermal phase-transition within the MIP-S network. Specifically, below the transition temperature (e.g., 20 °C), the MIP-S showed a highly specific recognition for the imprint species (adenine). However, the MIP-S did not show any significant resolution for the imprint species (adenine) and its analogue (1-methyladenine) above the transition temperature (e.g., 40 °C). Such temperature-regulated recognition is comparable to a switch-on and switch-off process, thereby making tunable molecular recognition feasible. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 2352–2360, 2009

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