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HPMC-salicylate conjugates as macromolecular prodrugs: Design, characterization, and nano-rods formation

  1. Muhammad A. Hussain1,*,
  2. Munair Badshah2,
  3. Mohammad S. Iqbal3,
  4. Muhammad N. Tahir4,
  5. Wolfgang Tremel4,
  6. Sheshanath V. Bhosale5,
  7. Muhammad Sher1,
  8. Muhammad T. Haseeb2

Article first published online: 8 JUL 2009

DOI: 10.1002/pola.23463

Issue

Journal of Polymer Science Part A: Polymer Chemistry

Journal of Polymer Science Part A: Polymer Chemistry

Volume 47, Issue 16, pages 4202–4208, 15 August 2009

Additional Information

How to Cite

Hussain, M. A., Badshah, M., Iqbal, M. S., Tahir, M. N., Tremel, W., Bhosale, S. V., Sher, M. and Haseeb, M. T. (2009), HPMC-salicylate conjugates as macromolecular prodrugs: Design, characterization, and nano-rods formation. J. Polym. Sci. A Polym. Chem., 47: 4202–4208. doi: 10.1002/pola.23463

Author Information

  1. 1

    Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan

  2. 2

    Department of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan

  3. 3

    Department of Chemistry, GC University, Lahore, Pakistan

  4. 4

    Institute of Inorganic and Analytical Chemistry, Johannes Guttenberg University, Duesbergweg 10-14, 55099 Mainz, Germany

  5. 5

    School of Chemistry, Monash University, Clayton, Victoria 3800, Australia

*Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan

Publication History

  1. Issue published online: 8 JUL 2009
  2. Article first published online: 8 JUL 2009
  3. Manuscript Accepted: 7 APR 2009
  4. Manuscript Received: 27 JAN 2009

Funded by

  • Higher Education Commission of Pakistan

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Keywords:

  • colon targeted drug delivery;
  • esterification;
  • nano-rods;
  • polysaccharides;
  • salicylic acid;
  • self-assembly
Thumbnail image of graphical abstract

Hydroxypropylmethylcellulose (HPMC) is a neutral, nonionic, acid resistant, and hydrolysable in basic medium. Keeping in view these properties, HPMC-salicylic acid conjugates, that is, macromolecular prodrugs were successfully synthesized, purified, and characterized by gel permeation chromatography, thermal analysis (TGA/DTA/DSC) and UV, FTIR, 1H NMR spectroscopic techniques. Chemical attachment (covalent) of the salicylic acid on HPMC and purity of products was verified by spectroscopic analyses. UV spectroscopy has indicated the incorporation of the drug in the conjugates after in vitro release in basic medium. Transmission electron microscopy has shown formation of nano-rods because of amphiphilic nature of products (HPMC-salicylate). All the samples synthesized were found thermally as stable as native HPMC. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

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