• block copolymers;
  • micelle;
  • microencapsulation;
  • nanocarrier;
  • nanoparticles;
  • photo responsive;
  • reverse micelle;
  • stimuli-sensitive polymers


A novel photo and thermo double-responsive block copolymer was developed to fabricate micelles and reverse micelles in aqueous solution. The block copolymer was synthesized by ATRP block copolymerization of a spiropyran- containing methacrylate (SPMA) with di(ethylene glycol) methyl ether methacrylate (DEGMMA). By facile control of the photo irradiation and solution temperature, PSPMA-core and PDEGMMA-core micelles can be obtained, respectively. The thermo- and photo-responsive micelles were used as smart polymeric nanocarriers for controlled encapsulation, triggered release, and re-encapsulation of model drug coumarin 102. The double-responsive self-assembly and disassembly were tracked by dynamic light scattering, transmission electron microscopy, and fluorescence spectroscopy. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2855–2861, 2010