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Micelles and reverse micelles with a photo and thermo double-responsive block copolymer

Authors

  • Qiao Jin,

    1. Department of Polymer Science, Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Zhejiang University, Hangzhou 310027, China
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  • Gongyan Liu,

    1. Department of Polymer Science, Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Zhejiang University, Hangzhou 310027, China
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  • Jian Ji

    Corresponding author
    1. Department of Polymer Science, Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Zhejiang University, Hangzhou 310027, China
    • Department of Polymer Science, Key Laboratory of Macromolecule Synthesis and Functionalization of Minster of Education, Zhejiang University, Hangzhou 310027, China
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Abstract

A novel photo and thermo double-responsive block copolymer was developed to fabricate micelles and reverse micelles in aqueous solution. The block copolymer was synthesized by ATRP block copolymerization of a spiropyran- containing methacrylate (SPMA) with di(ethylene glycol) methyl ether methacrylate (DEGMMA). By facile control of the photo irradiation and solution temperature, PSPMA-core and PDEGMMA-core micelles can be obtained, respectively. The thermo- and photo-responsive micelles were used as smart polymeric nanocarriers for controlled encapsulation, triggered release, and re-encapsulation of model drug coumarin 102. The double-responsive self-assembly and disassembly were tracked by dynamic light scattering, transmission electron microscopy, and fluorescence spectroscopy. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2855–2861, 2010

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