Article

Synthesis of amphiphilic block copolymers bearing stable nitroxyl radicals

  1. Xiuli Zhuang1,2,
  2. Chunsheng Xiao2,
  3. Kenichi Oyaizu1,
  4. Natsuru Chikushi1,
  5. Xuesi Chen2,*,
  6. Hiroyuki Nishide1,*

Article first published online: 13 OCT 2010

DOI: 10.1002/pola.24345

Issue

Journal of Polymer Science Part A: Polymer Chemistry

Journal of Polymer Science Part A: Polymer Chemistry

Volume 48, Issue 23, pages 5404–5410, 1 December 2010

Additional Information

How to Cite

Zhuang, X., Xiao, C., Oyaizu, K., Chikushi, N., Chen, X. and Nishide, H. (2010), Synthesis of amphiphilic block copolymers bearing stable nitroxyl radicals. J. Polym. Sci. A Polym. Chem., 48: 5404–5410. doi: 10.1002/pola.24345

Author Information

  1. 1

    Department of Applied Chemistry, Waseda University, Tokyo 169-8555, Japan

  2. 2

    Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

*Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Publication History

  1. Issue published online: 28 OCT 2010
  2. Article first published online: 13 OCT 2010
  3. Manuscript Accepted: 25 AUG 2010
  4. Manuscript Received: 13 JUN 2010

Funded by

  • G-COE Program, Waseda University and National Natural Science Foundation of China. Grant Numbers: 50733003, 50573078, 50773081

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Keywords:

  • block copolymers;
  • bioimaging;
  • ESR/EPR;
  • micelles;
  • nitroxyl radical

Abstract

We present here the synthesis of two kinds of amphiphilic block copolymers, a diblock copolymer MPEG-b-PTAm and a triblock copolymer MPEG-b-PLA-b-PTAm, which can self-assemble into micelles with nitroxyl radicals-containing PTAm segment in the core. The structure of the block copolymers was characterized by 1H NMR and GPC. Dynamic laser light scattering and transmission electron microscopy were used to study the micellar behavior of the two block copolymers in aqueous solution. The micelles carrying nitroxyl radicals in the core can generate electron paramagnetic resonance, which is stable for a period of time up to 8 min even in the presence of reducing reagent such as ascorbic acid. The enhanced stability against the reducing agent was ascribed to the inaccessibility of the nitroxyl radical core placed in the interior of the micelles. Combined with the biocompatibility, these micelles were promising to be used as the EPR probes for bioimaging in vivo. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010

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