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Novel poly(ethylene glycol) monomers bearing diverse functional groups

Authors

  • Dana M. Mizrahi,

    Corresponding author
    1. Department of Chemistry, Bar Ilan Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel
    Current affiliation:
    1. Israel Institute for Biological Research, Organic Chemistry Department, P.O. Box 19, Ness-Ziona 74100, Israel
    • Department of Chemistry, Bar Ilan Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel
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  • Melany Omer-Mizrahi,

    1. Department of Chemistry, Bar Ilan Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel
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  • Jenny Goldshtein,

    1. Department of Chemistry, Bar Ilan Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel
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  • Nataly Askinadze,

    1. Department of Chemistry, Bar Ilan Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel
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  • Shlomo Margel

    1. Department of Chemistry, Bar Ilan Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel
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Abstract

Poly(ethylene glycol) (PEG) mono methacrylate ester (MAPEG) has been used, through a variety of reactions, to form several novel monomers, bearing both a polymerizable handle and various functional groups. These new compounds may be conjugated to biomolecules via amine, acid, or thiol moieties or they may form dendrimers via the epoxide. In addition, polymerization of these monomers may result in functionalized nanoparticles and microparticles or coatings, thus altering the acid-base or electrochemical properties of surfaces and particles. Full synthetic considerations, including interesting intermediates, are reported. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010

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