Size and morphology controllable core cross-linked self-aggregates from poly(ethylene glycol-b-succinimide) copolymers

Authors

  • Chan Woo Park,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
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  • Hyun Jin Lee,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
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  • Hee-man Yang,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
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  • Min-ah Woo,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
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  • Hyun gyu Park,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
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  • Jong-Duk Kim

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
    • Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea
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Abstract

We developed a simple route to prepare stabilized micelles and nanovesicles in aqueous solutions. A hydrophobic poly(succinimide) (PSI) was conjugated with the hydrophilic poly(ethylene glycol) (PEG) as a new type of cross-linkable unit. Spherical aggregates were formed when dissolving the amphiphilic PEG682-b-PSI130 copolymer in aqueous solutions directly, and polymer nanovesicles were prepared by a precipitation-dialysis method using PEG455-b-PSI130 copolymer. Bifunctional primary amine was added to the micelle or nanovesicle solutions to prepare cross-linked structures via aminolysis reaction of the succinimide units. The degree of cross-linking was controlled by adjusting the molar ratio of the cross-linker to the succinimide units. Increasing the degree of cross-linking leads to the compaction of the micelle core thus reduced diameter. The cross-linked polymer micelles or nanovesicles maintained their morphology in extremely diluted solutions because of their structural stability. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010

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