Generation of well-defined clickable glycopolymers from aqueous RAFT polymerization of isomaltulose-derived acrylamides

Authors

  • Ouaiss Abdelkader,

    1. INSA-Lyon, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, F-69621, Villeurbanne Cedex, France
    2. ICBMS, UMR 5246; CNRS; Université de Lyon; Université Lyon 1; INSA-Lyon; CPE-Lyon; F-69621, Villeurbanne Cedex, France
    3. Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, Ingénierie des Matériaux Polymères (UMR-CNRS 5223), F-69621, Villeurbanne Cedex, France
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  • Sylvie Moebs-Sanchez,

    1. INSA-Lyon, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, F-69621, Villeurbanne Cedex, France
    2. ICBMS, UMR 5246; CNRS; Université de Lyon; Université Lyon 1; INSA-Lyon; CPE-Lyon; F-69621, Villeurbanne Cedex, France
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  • Yves Queneau,

    Corresponding author
    1. INSA-Lyon, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, F-69621, Villeurbanne Cedex, France
    2. ICBMS, UMR 5246; CNRS; Université de Lyon; Université Lyon 1; INSA-Lyon; CPE-Lyon; F-69621, Villeurbanne Cedex, France
    • INSA-Lyon, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, F-69621, Villeurbanne Cedex, France
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  • Julien Bernard,

    1. Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, Ingénierie des Matériaux Polymères (UMR-CNRS 5223), F-69621, Villeurbanne Cedex, France
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  • Etienne Fleury

    Corresponding author
    1. Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, Ingénierie des Matériaux Polymères (UMR-CNRS 5223), F-69621, Villeurbanne Cedex, France
    • Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, Ingénierie des Matériaux Polymères (UMR-CNRS 5223), F-69621, Villeurbanne Cedex, France
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Abstract

Original carbohydrate-based acrylamides bearing one azide group in C-2 or C-6 position namely, 2-[(2-deoxy-2-azido-α-D-mannopyranosyloxy)ethanamido]-ethyl acrylamide (II) and 2-[(6-deoxy-6-azido-α-D-glucopyranosyloxy)ethanamido]-ethyl acrylamide (III), and their azide-free analogue, 2-[(α-D-glucopyranosyloxy)ethanamido]-ethyl acrylamide (I), have been designed. Whereas the reversible addition fragmentation chain transfer (RAFT) process ensured the preparation of well-defined glycopolymers from I, the polymerization of monomers II and III proved to be challenging at temperatures compatible with a thermally initiated radical process, due to the presumed concomitant 1,3-cycloaddition reactions between the azide and the acrylamide moieties. In contrast to III, for which no polymer could be obtained under any conditions, performing the RAFT polymerization of II at 30 °C clearly favored the radical polymerization and conferred a controlled character to the process, affording well-defined azide-functionalized glycopolymers and block copolymers. The presence of numerous azide moieties was finally exploited to introduce carbohydrates onto the glycopolymer backbone through copper catalyzed azide-alkyne cycloaddition. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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