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Biomaterials based on low cytotoxic vinyl esters for bone replacement application

Authors

  • Branislav Husár,

    1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163/MC, 1060 Vienna, Austria
    2. Polymer Institute, Slovak Academy of Sciences, Dúbravská cesta 9, 845 41 Bratislava 45, Slovakia
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  • Christian Heller,

    1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163/MC, 1060 Vienna, Austria
    2. Institute of Materials Science and Technology, Vienna University of Technology, Favoritenstraße 9–11, 1040 Vienna, Austria
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  • Martin Schwentenwein,

    1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163/MC, 1060 Vienna, Austria
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  • Andreas Mautner,

    1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163/MC, 1060 Vienna, Austria
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  • Franz Varga,

    1. Ludwig Boltzmann Institute of Osteology, Vienna Hanusch-Hospital, Heinrich-Collin-Straße 30, 1140 Vienna, Austria
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  • Thomas Koch,

    1. Institute of Materials Science and Technology, Vienna University of Technology, Favoritenstraße 9–11, 1040 Vienna, Austria
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  • Jürgen Stampfl,

    1. Institute of Materials Science and Technology, Vienna University of Technology, Favoritenstraße 9–11, 1040 Vienna, Austria
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  • Robert Liska

    Corresponding author
    1. Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163/MC, 1060 Vienna, Austria
    • Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163/MC, 1060 Vienna, Austria
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Abstract

In recent days, additive manufacturing technologies (AMT) based on photopolymerization have also found application in tissue engineering. Although acrylates and methacrylates have excellent photoreactivity and afford photopolymers with good mechanical properties, their cytotoxicity and degradation products disqualify them from medical use. Within this work, (meth)acrylate-based monomers were replaced by vinyl esters with exceptional low cytotoxicity. The main focus of this paper lies on the determination of the photoreactivity and investigations concerning mechanical properties and degradation behavior of the new materials. Tested monomers provide sufficient photoreactivity for processing by AMT. Mechanical properties similar to natural bone could be obtained by adding suitable fillers like hydroxylapatite (HA). The right ratio of hydrophobic and hydrophilic monomers allows the tuning of the degradation behavior. Finally, with the optimum formulation, cellular 3D structures were built using digital light processing. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.

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