Cover Image, Volume 50, Issue 2


original image

Suitable in vitro models for investigating the nanometer-scale safety of drug delivery systems intended for intravenous injection are presented on page 217 by Andreas M. Nyström and colleagues. The image depicts a macrophage consuming polymer micelles constructed from a dendritic linear hybrid material that is releasing the chemotherapeutic doxorubicin intended for breast cancer therapy. For intravenous-injected drug delivery systems, the first line of immunological defense the particles will meet in vivo are the macrophages, suggesting that these are a good candidate model for toxicity testing. In this work primary cells from healthy blood donors are utilized to evaluate nanoparticle toxicity.