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Multifunctional nanoparticles labeled with fluorescent dyes and polymer chains intended for non-specific binding of antibacterial agents are presented on page 2533 by Brian Benicewicz and colleagues. The image depicts a nanoparticle labeled with fluorescent dyes attached to the surface of the nanoparticle to enable detection and tracking in biological systems such as bacterial biofilms. Reversible addition-fragmentation chain transfer (RAFT) polymerization is used to attach polymer chains to the surface of the nanoparticle with control over the chain density, molecular weight, polydispersity, and chemical functionality of the attached chains.