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Easy and effective method to produce functionalized particles for cellular uptake

Authors

  • Floraine Collette,

    1. Laboratoire de Chimie des Polymères Organiques, UMR CNRS 5629-IPB-ENSCBP-Université Bordeaux 1, 16 avenue Pey-Berland, F-33607 Pessac cedex, France
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  • Régis Delatouche,

    1. Laboratoire Synthèse et Réactivité des Substances Naturelles, UMR CNRS 6514, 40 Avenue du Recteur Pineau, 86022, Poitiers cedex, France
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  • Christophe Blanquart,

    1. INSERM, U892, Institut de Recherche Thérapeutique, Centre de Recherche en Cancérologie Nantes-Angers-8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France
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  • Fabien Gueugnon,

    1. INSERM, U892, Institut de Recherche Thérapeutique, Centre de Recherche en Cancérologie Nantes-Angers-8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France
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  • Marc Grégoire,

    1. INSERM, U892, Institut de Recherche Thérapeutique, Centre de Recherche en Cancérologie Nantes-Angers-8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France
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  • Philippe Bertrand,

    1. Laboratoire Synthèse et Réactivité des Substances Naturelles, UMR CNRS 6514, 40 Avenue du Recteur Pineau, 86022, Poitiers cedex, France
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  • Valérie Héroguez

    Corresponding author
    1. Laboratoire de Chimie des Polymères Organiques, UMR CNRS 5629-IPB-ENSCBP-Université Bordeaux 1, 16 avenue Pey-Berland, F-33607 Pessac cedex, France
    • Laboratoire de Chimie des Polymères Organiques, UMR CNRS5629-IPB-ENSCBP-Université Bordeaux 1, 16 avenue Pey-Berland, F-33607 Pessac cedex, France
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Abstract

In this contribution, a versatile approach for the synthesis of functionalized particles for drug delivery is presented, using two nonaggressive standardized procedures. The first procedure considered is the functionalization of an azido-terminated α-norbornenyl poly(ethylene oxide) (PEO) macromonomer with an alkyne-containing active molecule via the copper catalyzed azide alkyne cycloaddition, click type reaction. The functionalized macromonomer is then polymerized by Ring-Opening Metathesis Polymerization (ROMP) in dispersion to form functionalized particles. The second procedure consists in synthesizing particles by ROMP in dispersed media of norbornene with azido-terminated α-norbornenyl PEO macromonomer. The ROMP was initiated by the first generation Grubbs catalyst. Such functionalized core-shell particles have stealthy properties due to their PEO shell and can be viewed as universal nanocarriers on which any alkyne-modified active molecule can be grafted by click chemistry. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013

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