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Synthesis and characterization of poly(N-vinyl formamide) hydrogels—A potential alternative to polyacrylamide hydrogels

Authors

  • Tiffany C. Suekama,

    1. Chemical & Petroleum Engineering, 1530 West 15th Street, University of Kansas, Lawrence, Kansas 66045-7609
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  • Vara Aziz,

    1. Bioengineering Program, 1520 West 15th Street, University of Kansas, Lawrence, Kansas 66045-7609
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  • Zahra Mohammadi,

    1. Chemical & Petroleum Engineering, 1530 West 15th Street, University of Kansas, Lawrence, Kansas 66045-7609
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  • Cory Berkland,

    1. Chemical & Petroleum Engineering, 1530 West 15th Street, University of Kansas, Lawrence, Kansas 66045-7609
    2. Department of Pharmaceutical Chemistry, 2095 Constant Ave, University of Kansas, Lawrence, Kansas 66045-7609
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  • Stevin H. Gehrke

    Corresponding author
    1. Chemical & Petroleum Engineering, 1530 West 15th Street, University of Kansas, Lawrence, Kansas 66045-7609
    2. Bioengineering Program, 1520 West 15th Street, University of Kansas, Lawrence, Kansas 66045-7609
    3. Department of Pharmaceutical Chemistry, 2095 Constant Ave, University of Kansas, Lawrence, Kansas 66045-7609
    • University of Kansas, Chemical & Petroleum Engineering, 1530 W. 15th St., 4132 Learned Hall, Lawrence 66045-7609, Kansas
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Abstract

The synthesis and characterization of solution-cast, molded gels of N-vinyl formamide (NVF) has not been previously reported even though NVF is an isomer of acrylamide (AAm) and polyacrylamide (PAAm) hydrogels have many commercial applications. Aqueous NVF solutions were cross-linked into gels using a novel cross-linker, 2-(N-vinylformamido)ethylether, and the thermally-activated initiator VA-044. For a given formulation, PNVF gels swell up to twice that of PAAm gels cross-linked with N,N′-methylenebisacrylamide. From swelling and compression measurements, PNVF gels were found to be more hydrophilic than PAAm gels. Flory-Huggins solubility parameters were χ = 0.38ϕ2 + 0.48 for PNVF and χ = 0.31ϕ2 + 0.49 for PAAm, where ϕ2 is the polymer volume fraction. The shear moduli for PNVF and PAAm scale with ϕmath image and ϕmath image respectively, consistent with good solvent behavior, also suggesting PNVF is more hydrophilic than PAAm. Similarity of mechanical properties for both gels as a function of ϕ2 suggests that network structures of PNVF and PAAm gels are similar. Fracture strains of both gels declined with ϕ2 by the same linear function while fracture stresses were about 500 kPa regardless of formulation. Since NVF is a liquid monomer, less toxic than AAm and can be hydrolyzed to a cationic form, PNVF gels could become technologically significant. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013

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