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Article
pH-responsive destabilization and facile bioconjugation of new hydroxyl-terminated block copolymer micelles
Article first published online: 9 JAN 2013
DOI: 10.1002/pola.26533
Copyright © 2013 Wiley Periodicals, Inc.
Issue
Journal of Polymer Science Part A: Polymer Chemistry
Volume 51, Issue 7, pages 1620–1629, 1 April 2013
Additional Information
How to Cite
Khorsand, B. and Oh, J. K. (2013), pH-responsive destabilization and facile bioconjugation of new hydroxyl-terminated block copolymer micelles. J. Polym. Sci. A Polym. Chem., 51: 1620–1629. doi: 10.1002/pola.26533
Publication History
- Issue published online: 26 FEB 2013
- Article first published online: 9 JAN 2013
- Manuscript Accepted: 10 DEC 2012
- Manuscript Received: 13 OCT 2012
Keywords:
- amphiphilic block copolymer;
- atom transfer radical polymerization (ATRP);
- bioconjugation;
- controlled release;
- diblock copolymers;
- drug delivery systems;
- micelles;
- pH-responsive degradation;
- POEMA;
- PtBMA
Abstract
New hydroxyl-terminated amphiphilic block copolymers (HO-ABPs) having pendant t-butyl groups for pH-responsiveness and terminal OH groups for bioconjugation are reported. These HO-ABPs consist of hydrophilic poly(oligo(ethylene oxide) monomethyl ether methacrylate) and hydrophobic poly(t-butyl methacrylate) blocks and were synthesized by a consecutive atom transfer radical polymerization in the presence of an OH-terminated bromine initiator. Aqueous self-assembly of HO-ABPs resulted in colloidally stable micellar aggregates being capable of encapsulating hydrophobic guest molecules. They were nontoxic to cells and destabilized in response to low pH. A facile bioconjugation of HO-ABP micelles for active targeting is demonstrated by conjugation with biotin (vitamin H) and competitive assay exhibiting >93% ABP chains conjugated with biotin in each micelle. © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013