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Electrochemiluminescence biosensor for Ramos cells based on a nanostructured conducting polymer composite material (PICA-MWNTs)

Authors

  • Guangming Nie,

    1. State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
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  • Zhimin Bai,

    1. State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
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  • Wenying Yu,

    1. State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
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  • Lin Zhang

    Corresponding author
    • State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China
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Correspondence to: G. Nie (E-mail: gmnie@126.com)

ABSTRACT

A novel nanostructured conducting polymer (PICA-MWNTs) is easily prepared by direct electrodeposition of indole-6-carboxylic acid (ICA) and carboxylic groups ended multiwalled carbon nanotubes (MWNTs) in acetonitrile in one step. The resulting PICA-MWNTs composites with larger specific surface area and quite a few functionalized carboxylic acid groups are naturally integrated as a continuous uniform film on the electrode. CdSe quantum dots electrochemiluminescence biosensor with high sensitivity for detection of Ramos cells is fabricated based on PICA-MWNTs. Coupled with nanoparticle-amplification technnique, this sensor shows high sensitivity and good selectivity for Ramos cells with a low detection limit of 390 cells mL−1. This result provides an avenue for a simple and sensitive approach for detection of Ramos cells, which may have great potential in clinical applications. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 2385–2392

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