Synthetic glycopolymers containing pendant saccharide moieties are employed as multivalent natural oligosaccharide mimics in many biological and biomedical applications such as macromolecular drugs and drug delivery systems. Besides syntheses, the investigation into lectin-glycopolymer interactions is also vital for the application of glycopolymers. Y. Gou, J. Geng, S.-J. Richards, J. Burns, C. R. Becer, and D. M. Haddleton on page 2588 show that the diversities of binding properties contributed by different clustering parameters can make it possible to define the structures of the multivalent ligands and densities of binding epitopes for specific functions in the lectin-ligand interactions. The cover shows a schematic representation of the glycopolymer-lectin binding.