Cover Image, Volume 51, Issue 18
Article first published online: 5 AUG 2013
Copyright © 2013 Wiley Periodicals, Inc.
Journal of Polymer Science Part A: Polymer Chemistry
Volume 51, Issue 18, pages i–ii, 15 September 2013
How to Cite
(2013), Cover Image, Volume 51, Issue 18. J. Polym. Sci. A Polym. Chem., 51: i–ii. doi: 10.1002/pola.26876
- Issue published online: 5 AUG 2013
- Article first published online: 5 AUG 2013
- Cited By
An ornithine-based poly(ester amide) (above left) degrades more rapidly than a lysine-based PEA (below right) because it is capable of intramolecular cyclization (yellow scissors) upon light-triggered deprotection, in addition to hydrolysis (blue scissors). Nanoparticles formulated from the ornithine-based PEA thus disassemble rapidly, releasing cargo. By quantifying the amount of cyclization and ester hydrolysis, Caroline de Gracia Lux, Jason Olejniczak, Nadezda Fomina, Mathieu L. Viger, and Adah Almutairi demonstrate on page 3783 that only the polymer capable of forming a 6-membered ring cyclizes. This work introduces intramolecular cyclization as an efficient mechanism that can be incorporated into other polymeric materials for on-demand degradation.