Cover Image, Volume 52, Issue 5



On page 596, Sanghun Han and Yong-beom Lim report on the development of polyacrylamide gel stabilization electrophoresis (PASE) technology to covalently capture, physically constrain, and stabilize biologically active α-helical peptides (green) into a polyacrylamide hydrogel network (white). They synthesized a bioactive RNA-binding helical peptide with acryloyl groups at both ends of the peptide, covalently captured in its bioactive helical conformation into the polyacrylamide network via radical polymerization, and investigated whether the peptide can specifically recognize its target RNA molecule. This newly developed technology has the potential to be applied in many applications in which specific biomacromolecular recognition is necessary within a polymer hydrogel network.