Limitations of radical thiol-ene reactions for polymer–polymer conjugation (pages 1699–1713)
Sandy P. S. Koo, Milan M. Stamenović, R. Arun Prasath, Andrew J. Inglis, Filip E. Du Prez, Christopher Barner-Kowollik, Wim Van Camp and Thomas Junkers
Article first published online: 8 MAR 2010 | DOI: 10.1002/pola.23933
The ability of the radical thiol-ene reaction to serve as a click reaction for polymer–polymer conjugation has been tested on various systems. While functionalization of polymer chains with small molecules can be carried out without many problems, polymer–polymer conjugation could only be achieved when the thiol is in excess of the ene component. Thus, radical thiol-ene cannot be considered to be an efficient “click” reaction in a polymer conjugation context.