Cellulose diacetate and acetate butyrate were acylated with 2-bromoisobutyryl bromide or dichloroacetyl chloride to a various degree, giving monofunctional and bifunctional ATRP initiation sites. These were, however, combined with Cu(0) and appropriate ligands and for the first time used for grafting of (meth)acrylate monomers by SET-LRP method in DMSO. Grafting proceeded with acceptable rate at elevated temperature, nevertheless, the reaction conditions had to be optimized with respect to the monomer used. The grafts can be prolonged with other monomer to give block-copolymer-type grafts, e.g., p(HEMA-b-MMA-b-HEMA) amphiphilic triblocks. The products contained almost no catalytic residua and, therefore, did not require additional purification.