Jianxun Ding, Chunsheng Xiao, Li Zhao, Yilong Cheng, Lili Ma, Zhaohui Tang, Xiuli Zhuang and Xuesi Chen
Thermoresponsive and pH-responsive graft copolymers, poly(L-glutamate)-g-oligo(2-(2-(2-methoxyethoxy)ethoxy)ethyl methacrylate) and poly(L-glutamic acid-co-(L-glutamate-g-oligo(2-(2-(2-methoxyethoxy)ethoxy)ethyl methacrylate))), are synthesized by ring-opening polymerization and subsequent atom transfer radical polymerization. The thermal phase transition, secondary structure and self-assembly of graft copolymers can be tuned by the molecular weight of OMEO3MA, composition of PLGA backbone, temperature and pH. In vitro MTT assay reveals that the graft copolymers are biocompatible to HeLa cells. Therefore, with good biocompatibility, well-defined secondary structure, and mono-, dual-responsiveness, these graft copolymers are promising stimuli-responsive materials for biomedical applications.