Water-soluble, biocompatible polyphosphazenes with controllable and pH-promoted degradation behavior (pages 287–294)
Sandra Wilfert, Aitziber Iturmendi, Wolfgang Schoefberger, Kushtrim Kryeziu, Petra Heffeter, Walter Berger, Oliver Brüggemann and Ian Teasdale
Article first published online: 22 NOV 2013 | DOI: 10.1002/pola.27002
Hydrophilic graft polyphosphazenes with excellent water solubility and tailored hydrolytic degradability were successfully synthesized. Degradation of these polymers show a pH-promoted response with degradation rates ranging from days to months, relevant for use in the field of aqueous biomedical applications such as polymer drug delivery. Biocompatibility and the benign nature of the polymers and degradation products are confirmed by preliminary cell viability testing.