Modeling the swelling pressure of degrading hydroxyethylmethacrylate-grafted dextran hydrogels

Authors

  • B. G. Amsden,

    Corresponding author
    1. Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada, K7L 3N6
    • Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada, K7L 3N6
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  • B. G. Stubbe,

    1. Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • F. Horkay,

    1. Section on Tissue Biophysics and Biomimetics, National Institute of Child Health and Development, National Institutes of Health, 13 South Drive, Bethesda, Maryland 20892-5772
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  • S. C. De Smedt,

    1. Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • J. Demeester

    1. Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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Abstract

Degrading hydroxyethylmethacrylate-grafted dextran (dex-HEMA) hydrogels generate a relatively sudden increase in osmotic pressure upon degradation into dextran solutions. This phenomenon is currently being examined as a possible means of developing a pulsatile drug-delivery system. Here a mathematical model based on scaling concepts is presented to describe this sudden increase in swelling pressure and to provide a framework for the rational design of pulsatile delivery systems based on this phenomena. The model provides a good fit to the swelling pressures measured for dex-HEMA gel/free dextran mixtures that simulate degrading dex-HEMA gels. © 2004 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 42: 3397–3404, 2004

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