Structural design of stimuli-responsive bioconjugated hydrogels that respond to a target antigen

Authors

  • Takashi Miyata,

    Corresponding author
    1. Department of Chemistry and Materials Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
    2. PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
    3. High Technology Research Center, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
    • Department of Chemistry and Materials Engineering, Kansai University, Yamate-cho, Suita, Osaka, Japan
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  • Noriko Asami,

    1. Department of Chemistry and Materials Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
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  • Tadashi Uragami

    1. Department of Chemistry and Materials Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
    2. High Technology Research Center, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan
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Abstract

Stimuli-responsive bioconjugated hydrogels that can respond to a target antigen (antigen-responsive hydrogels) were prepared by introducing antigen-antibody bindings as reversible crosslinks into the gel networks. The preparation conditions of the antigen-responsive hydrogels and the mechanism of the antigen-responsive behavior were investigated, focusing on bioconjugated hydrogel structures. This article also focuses on the effect of semi-interpenetrating polymer network (semi-IPN) structures on the antigen-responsive swelling/shrinking behavior of bioconjugated hydrogels with antigen-antibody bindings. The preparation conditions and the network structures of the bioconjugated hydrogels are discussed in relation to designing antigen-responsive hydrogels. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 2144–2157, 2009

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