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The cover image shows an electron micrograph of a PLGA fiber scaffold that has been seeded with fibroblasts (false-colored). A number of cells can bridge the micrometer-scale gap between fiber rails. As outlined in the Review by Aftin Ross and Joerg Lahann on page 775, this type of control over three-dimensional scaffold microstructure is one of the important design criteria for scaffolds, in addition to material choice, ligand presentation, and the like (image credit: T. Eyster and J. Jordahl).