Ifosfamide neuropsychiatric toxicity in patients with cancer
Article first published online: 2 FEB 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 16, Issue 10, pages 956–960, October 2007
How to Cite
Alici-Evcimen, Y. and Breitbart, W. S. (2007), Ifosfamide neuropsychiatric toxicity in patients with cancer. Psycho-Oncology, 16: 956–960. doi: 10.1002/pon.1161
- Issue published online: 26 SEP 2007
- Article first published online: 2 FEB 2007
- Manuscript Accepted: 16 DEC 2006
- Manuscript Revised: 5 DEC 2006
- Manuscript Received: 20 MAY 2006
- neuropsychiatric toxicity;
Ifosfamide is a chemotherapy agent commonly used in the treatment of several solid tumors and hematologic malignancies. Common ifosfamide toxicities are bone marrow suppression, alopecia, nausea and vomiting. Less common, but striking, are the rare but dramatic neuropsychiatric toxicities with discrete neurological symptoms and delirium. We report here a case of ifosfamide neuropsychiatric toxicity which presented with an isolated psychotic disorder with delusions, and was successfully treated with methylene blue. Current literature on treatment and prophylaxis of this clinically challenging chemotherapy-induced complication is presented. Copyright © 2007 John Wiley & Sons, Ltd.