Prospective study of depression and fatigue in men with advanced prostate cancer receiving hormone therapy
Article first published online: 18 APR 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 17, Issue 2, pages 148–153, February 2008
How to Cite
Pirl, W. F., Greer, J. A., Goode, M. and Smith, M. R. (2008), Prospective study of depression and fatigue in men with advanced prostate cancer receiving hormone therapy. Psycho-Oncology, 17: 148–153. doi: 10.1002/pon.1206
- Issue published online: 22 JAN 2008
- Article first published online: 18 APR 2007
- Manuscript Accepted: 26 FEB 2007
- Manuscript Revised: 22 FEB 2007
- Manuscript Received: 23 AUG 2006
- Dana Foundation
- prostate cancer treatment
Purpose: We prospectively examined the development of depressive symptoms and fatigue among men with locally advanced prostate cancer receiving hormone therapy.
Methods: Fifty-two men with advanced or recurrent prostate cancer were randomly assigned to receive either parenteral leuprolide or oral bicalutamide. Patients completed the Beck Depression Inventory (BDI) and Fatigue Severity Scale (FSS) at pretreatment baseline, 6 months, and 12 months.
Results: Rates of at least mild depression ranged from 10.4 to 16.3% over the 12 months and were not significantly different at each time point. Mean change in BDI scores from baseline to 6 months for the entire sample was 0.91 (SE = 0.73), and from baseline to 12 months was 0.35 (SE = 0.67). Mean FSS scores increased significantly from baseline (M = 24.43, SD = 11.75) to 6 months (M = 27.93, SD = 13.52) and remained steady at 12 months (M = 27.80, SD = 14.44). There were no significant differences in depression between the two types of hormone therapy.
Conclusion: Hormone therapy does not appear to cause clinically significant changes in depression among men with locally advanced prostate cancer. However, fatigue increased significantly over the study period. Copyright © 2007 John Wiley & Sons, Ltd.