A portion of the baseline data was presented in poster format at the American Neuropsychiatric Association Annual Conference in 2003.
The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study†
Article first published online: 23 MAY 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 17, Issue 2, pages 122–130, February 2008
How to Cite
Stewart, A., Collins, B., Mackenzie, J., Tomiak, E., Verma, S. and Bielajew, C. (2008), The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study. Psycho-Oncology, 17: 122–130. doi: 10.1002/pon.1210
- Issue published online: 22 JAN 2008
- Article first published online: 23 MAY 2007
- Manuscript Accepted: 7 MAR 2007
- Manuscript Revised: 28 FEB 2007
- Manuscript Received: 4 AUG 2006
- breast cancer;
- adjuvant chemotherapy;
- cognitive function;
- adjuvant hormonal treatment
Purpose: The primary purpose of this study was to evaluate the cognitive effects of adjuvant chemotherapy in post-menopausal breast cancer patients.
Patients and methods: Breast cancer patients scheduled to receive adjuvant chemotherapy (n = 61) completed comprehensive cognitive testing before and after treatment. A control group of women receiving adjuvant hormonal therapy (n = 51) was tested at comparable intervals.
Results: Mean scores for both patient groups were within the normal range relative to published norms on all cognitive tests at both time points, and generally inclined or stayed the same from baseline to retest in both groups. However, in an analysis of individual change scores, the chemotherapy patients were 3.3 times more likely than the hormonal patients to show reliable cognitive decline (31 and 12%, respectively). Chemotherapy subjects showing decline were less educated and had higher baseline depression scores than their counterparts who did not decline. Working memory was the cognitive domain most vulnerable to the effects of chemotherapy.
Conclusion: These data support previous findings of a subtle negative influence of chemotherapy on cognitive function in a subgroup of breast cancer patients. The results are discussed in terms of the importance of study design. Copyright © 2007 John Wiley & Sons, Ltd.