Associations between cognitive impairment in advanced cancer patients and psychiatric disorders in their caregivers
Version of Record online: 26 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 22, Issue 4, pages 952–955, April 2013
How to Cite
Meyer, F., Zhang, B., Gao, X. and Prigerson, H. G. (2013), Associations between cognitive impairment in advanced cancer patients and psychiatric disorders in their caregivers. Psycho-Oncology, 22: 952–955. doi: 10.1002/pon.3076
- Issue online: 7 APR 2013
- Version of Record online: 26 MAR 2012
- Manuscript Accepted: 3 MAR 2012
- Manuscript Revised: 12 FEB 2012
- Manuscript Received: 14 DEC 2011
- cognitive impairment;
- psychiatric disorder
This study examined whether cognitive impairment in advanced cancer patients is associated with a heightened frequency of psychiatric disorders in their primary caregivers.
Three hundred fifty-six patient-caregiver dyads were interviewed and administered the Short Portable Mental Status Questionnaire and the Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition approximately 3.4 months before the patient's death. The Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition was administered to caregivers again approximately 6 months after the patient's death.
Forty-six (12.9%) patients displayed signs of mild cognitive impairment at the baseline interview. After adjustment for relevant confounders, patient cognitive impairment was significantly associated with caregiver pre-loss major depressive disorder [OR 6.88 (95% CI 1.32–35.92); p = 0.02], without associated increases in suicidality. There were no significant associations between patient cognitive impairment and caregiver pre-loss generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or grief. Likewise, there were no significant associations between patient cognitive impairment and caregiver post-loss psychiatric disorders, but caregivers of cognitively impaired patients appeared to be less satisfied with the patient's manner of death (p = 0.01).
Caregivers of cognitively impaired advanced cancer patients appear at heightened risk of major depression that resolves after the patient's death. Further study with a larger sample and more sensitive longitudinal cognitive measures is indicated. Copyright © 2012 John Wiley & Sons, Ltd.