Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions
Article first published online: 14 MAY 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 22, Issue 4, pages 862–868, April 2013
How to Cite
Nguyen, C. M., Yamada, T. H., Beglinger, L. J., Cavanaugh, J. E., Denburg, N. L. and Schultz, S. K. (2013), Cognitive features 10 or more years after successful breast cancer survival: comparisons across types of cancer interventions. Psycho-Oncology, 22: 862–868. doi: 10.1002/pon.3086
- Issue published online: 7 APR 2013
- Article first published online: 14 MAY 2012
- Manuscript Accepted: 27 MAR 2012
- Manuscript Revised: 19 MAR 2012
- Manuscript Received: 16 DEC 2011
- National Institute of Health. Grant Number: NCI R01CA122934
- National Institute on Aging Career Development. Grant Number: K01 AG022033
- breast cancer;
- neuropsychological assessment
The present study examined the long-term cognitive implications of cancer treatment among breast cancer survivors aged 65 years and older to better understand the long term implications of cancer treatment.
Fifty-seven women survivors were compared with 30 healthy older female adult comparisons, matched in terms of age and education, with no history of cancer. Cancer survivors were also compared on the basis of treatment intervention, involving chemotherapy (n = 27) versus local therapy through surgery and radiation (n = 30).
As a group, the breast cancer survivors scored lower on measures of general cognitive function, working memory, psychomotor speed, and executive function when compared with the normal comparisons. Among the cancer survivors, those who received local therapy scored lower than the other survivors and normal comparisons on measures of verbal learning, visual perception and construction, as well as visual attention and short-term retention.
Our findings suggest that cognitive outcomes may involve greater age-related deficits among older cancer survivors compared with matched healthy subjects. Copyright © 2012 John Wiley & Sons, Ltd.