Treating chemotherapy induced agranulocytosis with granulocyte colony-stimulating factors in a patient on clozapine
Article first published online: 12 OCT 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Volume 22, Issue 7, pages 1674–1675, July 2013
How to Cite
Kolli, V., Denton, K., Borra, D., Pulluri, M. and Sharma, A. (2013), Treating chemotherapy induced agranulocytosis with granulocyte colony-stimulating factors in a patient on clozapine. Psycho-Oncology, 22: 1674–1675. doi: 10.1002/pon.3209
- Issue published online: 5 JUL 2013
- Article first published online: 12 OCT 2012
- Manuscript Accepted: 25 SEP 2012
- Manuscript Revised: 16 SEP 2012
- Manuscript Received: 12 JUL 2012
- granulocyte colony-stimulating factor;
Clozapine is reserved for overcoming treatment resistance in schizophrenia. Malignancy is common in schizophrenia; however, there is limited evidence available on continuing clozapine with chemotherapy, with both having hematological adverse effects.
To report a case on the use of granulocyte colony-stimulating factor (G-CSF) in conjunction with clozapine and chemotherapy.
We searched PubMed for any available information on the use of granulocyte G-CSF with clozapine and chemotherapy. We report the case of a patient with schizophrenia who developed B-cell lymphoma and was treated with chemotherapy consisting of CHOP regimen, rituximab, and methotrexate. He was continued on clozapine and G-CSF.
We did not find any reports on G-CSF use in conjunction with clozapine and chemotherapy. We found case reports and a case series on the use of G-CSF in clozapine rechallenge with clozapine-induced agranulocytosis with mixed results. In our patient on clozapine, the white blood cell counts reduced by chemotherapy, were successfully replenished with the use of filgrastim, a G-CSF.
With risks of psychosis relapse and exacerbation with discontinuing clozapine, the addition of G-CSF could be a useful aid in replenishing white cell counts lost to chemotherapy whilst continuing clozapine. However, further study is needed on this combination. Copyright © 2012 John Wiley & Sons, Ltd.