Chemotherapy-induced prospective memory impairment in patients with breast cancer

Authors

  • Huaidong Cheng,

    1. Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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  • Zhen Yang,

    1. Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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  • Biao Dong,

    1. Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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  • Chanjuan Chen,

    1. Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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  • Mingjun Zhang,

    1. Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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  • Zhonglian Huang,

    1. Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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  • Zhendong Chen,

    Corresponding author
    • Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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  • Kai Wang

    Corresponding author
    • Neuropsychological Laboratory, Institute of Neurology and Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
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Correspondence to: Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, China.678 Furong Road, Hefei 230601, China. E-mail: chenzhendong@csco.org.cn.;

Neuropsychological Laboratory, Institute of Neurology and Department of Neurology, The First Affiliated Hospital of Anhui Medical University, China.218 Jixi Road, Hefei 230022, China. E-mail: wangkai1964@126.com

Abstract

Objective

This study aimed to investigate the event-based prospective memory (EBPM) and time-based prospective memory (TBPM) in chemotherapy-induced cognitive impairment in patients with breast cancer.

Methods

Forty patients with breast cancer who underwent adjuvant chemotherapy and 40 age-matched and education-matched healthy women were administered with a battery of neuropsychological tests including EBPM and TBPM tasks.

Results

A significant difference between breast cancer patients and controls was found in the scores on the mini-mental state examination (t = −11.684, p < 0.01), verbal fluency test (t = −7.939, p < 0.01), and digit span (t = −2.538, p < 0.05). Compared with healthy controls, breast cancer patients exhibited a poorer performance on EBPM (t = −7.096, p < 0.01) but not on TBPM (t = −1.921, p > 0.05).

Conclusions

Our results suggest that breast cancer patients who had undergone adjuvant chemotherapy show deficits in EBPM but not in TBPM. Copyright © 2013 John Wiley & Sons, Ltd.

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