Physical activity and quality of life in breast cancer survivors: the role of self-efficacy and health status

Authors

  • Siobhan M. Phillips,

    Corresponding author
    1. Department of Kinesiology and Community Health, University of Illinois at Urbana–Champaign, Urbana, IL, USA
    • Correspondence to: Division of Cancer Control and Population Sciences, Office of Cancer Survivorship, National Cancer Institute, 9609 Medical Center Drive, Office 4E516, Rockville, MD 20850, USA. E-mail: siobhan.phillips@mail.nih.gov

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  • Edward McAuley

    1. Department of Kinesiology and Community Health, University of Illinois at Urbana–Champaign, Urbana, IL, USA
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  • All work on this project was completed at the University of Illinois at Urbana–Champaign.

Abstract

Objective

Mechanisms underlying the relationship between physical activity and quality of life (QOL) in breast cancer survivors are not well understood. The purpose of the present study was to longitudinally test a model examining self-efficacy and health status as potential mediators of this relationship.

Methods

At baseline and 6 months, breast cancer survivors (n = 1527) completed physical activity, self-efficacy, health status, and QOL measures, and a subsample (n = 370) wore an accelerometer. Panel analysis within a covariance modeling framework was used to test the hypothesis that physical activity indirectly influences QOL across time.

Results

The hypothesized model provided a good fit in the full sample (χ2 = 409.06; d.f. = 91, p < 0.001; comparative fit index (CFI) = 0.98; standardized root mean residual (SRMR) = 0.04) and the accelerometer subsample (χ2 = 320.96, d.f. = 134, p < 0.001; CFI = 0.95; SRMR = 0.05), indicating that physical activity indirectly, via self-efficacy and health status indicators, influences QOL across time.

Conclusions

Physical activity may influence QOL in breast cancer survivors through more proximal, modifiable factors. Copyright © 2013 John Wiley & Sons, Ltd.

Introduction

Side effects of breast cancer treatment (e.g., fatigue, lymphedema, nausea, weight gain, and depression) [1, 2] are associated with a number of deleterious consequences including poorer disease-related outcomes and reduced quality of life (QOL) [3]. Many of these side effects persist, or even increase, several years post-diagnosis [3], and some may have a delayed onset or be irreversible [4, 5]. In addition, breast cancer survivors report significantly lower levels of health-related QOL (HRQOL) than non-cancer survivors [6, 7], and HRQOL has been associated with early treatment discontinuation [8], cancer recurrence [9], and reduced overall survival [10]. Physical activity is one lifestyle factor that has been shown to have significant QOL benefits for breast cancer survivors and has also been associated with enhanced survival and reduced risk of recurrence and mortality [11-14]. Although there is a substantial body of literature supporting beneficial effects of regular physical activity on QOL in breast cancer survivors [14], the mechanisms underlying this relationship are not well understood.

One of the major reasons for a lack of knowledge regarding such mechanisms may be the conceptualization of QOL in the cancer literature. The majority of studies examining physical activity and QOL in the breast cancer literature have focused solely on HRQOL [15], adopting the traditional medical literature's characterization of QOL as an ‘umbrella term’ under which a broad array of health status and disease outcomes reside. Few studies have classified QOL as a global psychological construct reflecting a ‘conscious cognitive judgment of one's current satisfaction with one's life’, or life satisfaction [16]. Although health status may be associated with global measures of QOL, these constructs are conceptually and theoretically independent [17, 18], limiting the focus on QOL to an umbrella term for multiple constructs limits theory development, understanding of variability and changes in QOL, and knowledge about the meaning of HRQOL and health status for cancer patients and survivors [19, 20]. Thus, understanding not only the mechanisms underlying the relationship between physical activity and health status, but also how health status relates to more global QOL may be particularly important in breast cancer survivors to identify important opportunities for intervention.

Research conducted in older women adopting a social cognitive perspective has demonstrated that changes in physical activity and global QOL may be mediated by more proximal psychosocial outcomes of physical activity participation including exercise self-efficacy and physical and mental health status [17]. Further support for this model has been provided in community-dwelling older adults [21] and individuals with multiple sclerosis [22], indicating that this model may be useful for understanding physical activity and QOL in breast cancer survivors, especially given that about 60% of breast cancer survivors are over the age of 65 years [23]. However, simply examining physical or mental health status may be insufficient, particularly for breast cancer survivors, given the various side effects and life changes that may occur post-diagnosis.

The present study was designed to explore the relationship between physical activity and QOL in a large geographically diverse sample of breast cancer survivors, by replicating and extending McAuley and colleagues' [17] model to include multiple indicators of health status associated with breast cancer survivorship. Additionally, we extended previous research, by measuring physical activity by accelerometry in a subsample of participants. Specifically, we hypothesized that baseline physical activity would be indirectly associated with global QOL via self-efficacy and health status indicators (social, physical, functional, and emotional). Self-efficacy was hypothesized to be indirectly associated with QOL through health status indicators, and each health status indicator was, in turn, proposed to have a direct effect on global QOL. Furthermore, these relationships were hypothesized to be invariable among changes in these constructs over a 6-month period while controlling for all other model variables and covariates including demographic, treatment, and disease-related characteristics.

Participants and methods

Participant eligibility criteria

Women over the age of 18 years, who had been diagnosed with breast cancer, were English speaking, and had access to a computer were eligible to participate in the present study.

Measures

Demographics

Self-reported marital status, age, race, ethnicity, occupation, income, and education were collected.

Health and cancer history

Participants were asked to indicate (yes or no) whether they have been diagnosed with a list of 18 comorbidities (i.e., diabetes, obesity, and hypertension) and to self-report information regarding breast cancer and other cancer history including date of diagnosis, treatment, and stage of disease. Current height and weight were also self-reported to estimate BMI.

Self-reported physical activity

The Godin Leisure Time Exercise Questionnaire [24] assessed self-reported frequency of current participation in at least 10 min of strenuous (e.g., jogging), moderate (e.g., fast walking), and mild (e.g., easy walking) exercise over the past 7 days. These frequencies were multiplied by nine, five, and three metabolic equivalents, respectively, and summed to obtain a total leisure time activity score.

Objective physical activity

The ActiGraph accelerometer (model GT1M version, Health One Technology, Fort Walton Beach, FL, USA), a valid and reliable objective physical activity measure [25, 26], was used to measure physical activity in a subsample of the study population. These women were instructed to wear the monitor for seven consecutive days on the non-dominant hip during all waking hours, except for when bathing or swimming. Activity data were collected in 1-min intervals (epochs). For the purposes of this study, a valid day of data consisted of an individual wearing the monitor for at least 10 valid hours with a valid hour being defined as having no more than 30 min of consecutive zeros. The total number of counts for each valid day were summed and divided by the number of days of monitoring to arrive at an average number of activity counts. Only data for individuals with a minimum of three valid days of wear time at both time points were included in the analyses [27].

Self-efficacy

The six-item Exercise Self-Efficacy Scale [28] assessed participants' beliefs in their ability to exercise five times per week, at a moderate intensity, for 30 or more minutes per session at 2-week increments over the next 12 weeks. The 15-item Barriers Self-Efficacy Scale [28] assessed participants' perceived capabilities to exercise three times per week for 40 min over the next 2 months in the face of common barriers to participation. Items from each scale are scored on a 100-point percentage scale with 10-point increments, ranging from 0% (not at all confident) to 100% (highly confident). For each measure, total scores are calculated using the average confidence rating.

Health status

The 27-item Functional Assessment of Cancer Therapy—General [29] measured participants' physical, social/family, emotional, and functional well-being. Participants were asked to indicate how true each of the items had been for them over the last 7 days on a five-point Likert scale ranging from 0 (not at all true) to 4 (very much true). Well-being subscale scores were calculated by multiplying the sum of the items from each subscale by the number of items in the subscale and then dividing by the number of items answered with higher scores indicating better QOL.

Global quality of life

The 5-item Satisfaction with Life Scale [30] assessed participants' agreement with each statement on a seven-point scale from 1 (strongly disagree) to 7 (strongly agree). The items are summed to obtain a total score with higher scores representing greater life satisfaction.

Recruitment and randomization

All study procedures and recruitment materials were approved by the University institutional review board. Participants were recruited using the Army of Women©, University email, fliers, and on-line community groups and postings. After expressing initial interest, women (n = 2546) were emailed a link to a full study description. Those meeting the eligibility criteria were extended an offer to participate and received an electronic version of the informed consent. Of those who qualified for participation and completed the informed consent (n = 1631), a subgroup of individuals (n = 500) were completely randomly assigned using a pre-populated computer algorithm to wear an accelerometer for 7 days at baseline and 6-month follow-up. Women who completed at least half of the study survey at baseline were re-sent a link to the questionnaires at 6 months, and women who had at least three valid days of accelerometer data at baseline were sent an accelerometer at 6 months. Thus, in the present study, 1527 women were included in the full sample analyses, and 370 women were included in the accelerometer subsample analyses.

Data collection

Women randomized to the survey only group were sent an individualized secure link to the study questionnaires. A study packet was prepared containing an accelerometer, related study materials, and a self-addressed stamped envelope for those women randomized to wear the accelerometer. The study survey link was emailed to women in the accelerometer subgroup when their accelerometer packet was mailed. All participants were asked to return study materials within 2 weeks of receipt. Reminder emails to the accelerometer subgroup were continued until the accelerometer was returned to study investigators. The same procedures were followed for both groups at 6 months.

Data analysis

To examine the hypothesized relationships, two separate panel analyses within a covariance framework were conducted in Mplus V6.0 [31]. Such an approach allowed us to examine the hypothesized relationships at baseline and those same relationships among changes in the constructs at 6 months, controlling for all other variables in the model. The first panel analysis tested the hypothesized model in all participants, whereas the second panel analysis tested the hypothesized model only in the subgroup of participants who had worn the accelerometer to determine whether physical activity measurement influenced model relationships. The following covariates were controlled for in each of the analyses: age, education, income, BMI, number of comorbidities, time since diagnosis, and stage of disease.

As a result of preliminary analyses indicating that missing data were missing at random, full-information maximum likelihood was used in the present study [32-34]. At baseline, the extent of missing data ranged from 9.5% (self-reported physical activity) to 15.1% (barriers self-efficacy). Missing data at 6 months ranged from 25.3% (self-reported physical activity) to 28.1% (physical well-being) and was largely the result of loss to follow-up.

The following hypothesized relationships were tested: (i) a direct path from physical activity to self-efficacy; (ii) a direct path from self-efficacy to each health status indicator (functional, emotional, social, and physical well-being); and (iii) a direct path from each health status indicator to global QOL. Self-efficacy was measured as a latent construct using the total scores from the Barrier Self-efficacy Scale and the Exercise Self-Efficacy Scale as indicators. In the accelerometer subsample, physical activity was modeled as a latent construct with the Godin Leisure Time Exercise Questionnaire total score and average accelerometer counts as indicators. Stability coefficients were calculated [35] to reflect correlations between the same variables measured in each model separately across time while controlling for the influence of other variables in the model.

The chi-square statistic assessed absolute fit of the model to the data [36]. The standardized root mean residual (SRMR) and comparative fit index (CFI) were also used to determine the fit of the model. SRMR values approximating 0.08 or less demonstrate close fit of the model [37, 38], whereas CFI values of 0.90 indicate a minimally acceptable fit value, and values approximating 0.95 or greater are indicative of a good fit [37].

Results

Participant characteristics

Prevalence of self-reported comorbidities and data regarding demographic, disease, and treatment characteristics at baseline have been reported elsewhere [39]. Briefly, study participants were a nationwide sample of middle-aged (M age = 56.2, SD = 9.4) and moderately overweight (M BMI = 26.6, SD = 5.74) breast cancer survivors. The sample consisted of mostly White (97.0%), non-Hispanic/Latino (98.5%), and highly educated women (67.0% had at least a college degree). The majority of women (86.0%) had an annual household income greater than or equal to $40,000, and about three-quarters of the sample reported having at least one comorbid condition (71.4%), with the most commonly reported comorbid conditions being arthritis (33.4%), osteoporosis (18.9%), and asthma (10.3%). Women were, on average, about 7 years post-diagnosis (M = 86.48 months, SD = 71.59), and most were diagnosed with early stage disease (83.6% diagnosed with ductal carcinoma in situ, stage 1 or 2 disease). The majority of the sample (99.3%) underwent surgery and received chemotherapy (59.0%) and/or radiation therapy (67.7%). Only 3.2% of the sample was currently receiving chemotherapy or radiation, and 10.7% had been diagnosed with breast cancer recurrence.

Physical activity and quality of life associations across time

The means, standard deviations, and t-values for each of the variables included in the model are displayed in Table 1. Briefly, over the 6-month study, there was a modest but significant (p < 0.05) decline in exercise self-efficacy and self-reported physical activity in the full study sample. In addition, physical activity measured by accelerometry also declined in the subsample who wore the monitors.

Table 1. Descriptions of quality of life model constructs at baseline and 6 months
VariableBaseline6 monthst-value
MSDMSD
  1. All values are for the full sample except for the accelerometer data, which are only for the subset who wore the accelerometer.

  2. a

    Significant at p  ≤ 0.05.

  3. b

    Measured as average accelerometer counts.

Self-efficacy     
Barriers self-efficacy47.7324.3246.7224.911.73
Exercise self-efficacy73.7832.6069.9234.764.56a
Health status     
Physical well-being23.934.2124.064.34−1.41
Functional well-being22.265.0322.464.88−1.66
Social well-being21.655.4221.685.73−0.22
Emotional well-being19.823.7419.933.64−1.19
Global quality of life25.836.6826.046.74−1.57
Self-reported physical activity31.7221.2130.4121.972.17a
Objective physical activityb252,219.97169,805.00212,765.2297,755.464.50a

Full sample

The proposed model provided an acceptable fit to the data (χ2 = 657.73; d.f. = 93, p < 0.001; CFI = 0.96; SRMR = 0.04). However, a specification search indicated that the model-data fit could be improved by adding a bidirectional correlation between barrier self-efficacy and exercise self-efficacy, independently, at each time point. The addition of these relationships is also consistent with social cognitive theory [40] and previous work examining trajectories of exercise self-efficacy across time [41] and resulted in an improved model-data fit (χ2 = 409.06; d.f. = 91, p < 0.001; CFI = 0.98; SRMR = 0.04). This model is shown in Figure 1. The top panel illustrates the relationships among constructs at baseline, whereas the bottom panel reflects relationships among changes in these constructs over the 6-month period while controlling for covariates and all other variables in the model. Overall, the stability coefficients were acceptable and ranged from 0.58 (self-reported physical activity) to 0.66 (self-efficacy and social well-being). The stability coefficients and bidirectional correlations have been omitted from the figure for the sake of clarity.

Figure 1.

Physical activity and quality of life in breast cancer survivors model in the full sample. Significant paths are represented by solid lines. Non-significant paths and stability coefficients were not included for clarity purposes

At baseline, more active breast cancer survivors reported significantly (p < 0.05) higher self-efficacy (β = 0.53). In turn, more efficacious women reported significantly higher physical (β = 0.29), emotional (β = 0.22), functional (β = 0.32), and social (β = 0.16) well-being. Finally, women reporting higher levels of emotional (β = 0.19), functional (β = 0.29), and social (β = 0.24) well-being also reported significantly higher global QOL. The direct path from physical well-being to global QOL was not significant. Furthermore, physical activity had statistically significant indirect effects on global QOL via self-efficacy and social, functional, and emotional well-being at baseline.

At 6-month follow-up, changes in physical activity were significantly associated with residual changes in self-efficacy (β = 0.30). Changes in self-efficacy were, in turn, significantly related to residual changes in physical (β = 0.14), functional (β = 0.18), emotional (β = 0.08), and social (β = 0.09) well-being. Changes in functional (β = 0.25), emotional (β = 0.08), and social (β = 0.07) well-being were significantly associated with residual changes in global QOL. The indirect effect of changes in physical activity on global QOL via self-efficacy and changes in emotional and social well-being was also significant at follow-up. Overall, the model accounted for 40.7% and 65.7% of the variance in global QOL at baseline and follow-up, respectively.

Accelerometer subgroup

Next, we tested the veracity of the model in the subsample with accelerometer data. This model also represented a good overall fit to the data (χ2 = 320.96, d.f. = 134, p = <0.001; CFI = 0.95; SRMR = 0.05) and is shown in Figure 2. Compared with the full sample, the relationships among model constructs at baseline were identical in terms of significance and very similar in terms of magnitude in the accelerometer subgroup. In addition, the majority of the relationships among changes in model constructs were similar to those demonstrated in the total sample. However, the relationship between changes in self-efficacy and residual changes in emotional and social well-being was not significant, whereas the relationship between physical well-being and global QOL became significant in the subsample. Overall, the model explained 49.7% and 64.3% of the variance in global QOL at baseline and follow-up, respectively.

Figure 2.

Physical activity and quality of life model in breast cancer survivors in the accelerometer subsample. Significant paths are represented by solid lines. Non-significant paths and stability coefficients were not included for clarity purposes

Discussion

The purpose of this study was to examine the relationship between physical activity, health status, and global QOL in a longitudinal sample of breast cancer survivors. McAuley and colleagues' [17] model was extended to breast cancer survivors using an objective measure of physical activity and breast cancer-specific measures of health status as mediators of the relationship between physical activity and global QOL. Increases in physical activity were associated with increases in self-efficacy, which, in turn, were associated with increases in health status indicators, which were each associated with increases in global QOL. Thus, these findings provide support for the perspective that (i) the relationship between physical activity and QOL across time in breast cancer survivors can be understood as incorporating more proximal, modifiable, and temporally sensitive factors (e.g., self-efficacy), as well as more stable and global constructs (e.g., satisfaction with life); and (ii) multiple indicators of health status can be used as outcomes of physical activity and predictors of global QOL across time.

That physical well-being was not directly related to global QOL at baseline and did not act as a mediator between physical activity and global QOL at baseline in both groups or at follow-up in the full sample was unexpected. In previous studies, physical health status has mediated the relationship between physical activity and global QOL [17, 21]. One potential explanation for the findings relative to physical well-being is that those items on the Functional Assessment of Cancer Therapy—General reflect how one's ‘illness’ is influencing their life. Because the average time since diagnosis was about 7 years, it is conceivable that this measure contains items that are neither relevant nor salient to these women as longer-term survivors. Consequently, these findings are to be interpreted with caution, and other indicators of physical health should be included in future examinations of these relationships in breast cancer survivors. In addition, differences in the significant pathways in the accelerometer subsample may indicate a potential bias that resulted as a function of how activity was measured. This may indicate that individuals who self-reported lower levels of health status may underreport their physical activity participation and vice versa. Objective measurement of physical activity reduces such a bias. Further testing of the hypothesized model using both self-report and objective physical activity measures is warranted.

Study findings represent an important first step in examining physical activity and global QOL in breast cancer survivors and determining potential mediators of this relationship. For example, it might be argued that health status and global QOL could be modified in breast cancer survivors if both physical activity and self-efficacy are targeted appropriately. Indeed, targeting self-efficacy as part of physical activity programs for breast cancer survivors may not only increase physical activity participation [42] but also result in greater improvements in health status and, in turn, global QOL. Such improvements have implications for the utilization of healthcare services, as well as serving as a motivating factor for the adoption, maintenance, and adherence to physical activity programs in breast cancer survivors.

However, as with all studies, this study is not without limitations. First, a longitudinal observational design was used. Randomized controlled exercise trials will be needed to determine whether proposed relationships among changes in model constructs are sustained as a result of an intervention. Second, minimal changes in model constructs were observed over the 6-month period, suggesting that either examining the mean values may not fully reflect variation in change over the 6-month study period or 6 months may not be a long enough period to observe mean level changes in these constructs. Finally, the study sample was largely homogeneous and may not be entirely representative of this population at large. Thus, it is important to examine whether this model holds in other more diverse samples of breast cancer survivors as well as within subgroups of this population (e.g., survivors within 5 years of diagnosis versus longer-term survivors, older versus younger survivors).

Nonetheless, this study does represent one of the largest, geographically diverse, longitudinal examinations of physical activity and QOL in breast cancer survivors to date. Moreover, we used an objective measure of physical activity. To the best of our knowledge, this is the only study that has examined the potential psychosocial pathways underlying the relationship between physical activity and global QOL in breast cancer survivors. These data underscore the importance of personal efficacy and health status in understanding global QOL in breast cancer survivors. The findings from this study can serve to inform future research and programming in regard to physical activity participation and outcomes in this population.

Future studies should replicate and refine the model presented, by including additional potential psychosocial constructs associated with health status (e.g., self-esteem, depression, functional limitations, and cognitive function) as well as potential biological mediators of these relationships (e.g., inflammatory biomarkers, and hormone levels). Additionally, the optimal time along the breast cancer continuum at which to intervene to maximize QOL benefits of a physical activity program has yet to be determined. Finally, as the demographic landscape of the country changes, it will be imperative to determine how physical activity influences health outcomes in the aging survivor population as older breast cancer survivors have been shown to have physical, social, and psychological health needs that may extend beyond those of the healthy aging population [7, 43]. In conclusion, these data provide evidence for the role of self-efficacy and health status indicators in understanding the relationship between physical activity and global QOL in breast cancer survivors. As the population ages, and advances in early detection and treatment progress, the number of breast cancer survivors will continue to increase. Findings from this study indicate that physical activity may play an important role in enhancing QOL in breast cancer survivors and can be used to inform future research and programs designed to enhance cancer survivorship.

Acknowledgments

This work was supported by the National Institute on Aging at the National Institutes of Health through award numbers F31AG034025 and AG020118, and the Shahid and Ann Carlson Khan endowed professorship.

Conflict of interest

Neither of the authors have any potential conflicts of interest.

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