These authors contributed equally to this work.
Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment
Article first published online: 15 APR 2014
Copyright © 2014 John Wiley & Sons, Ltd.
Volume 23, Issue 10, pages 1165–1171, October 2014
How to Cite
2014), Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment, Psycho-Oncology, 23: 1165–1171. DOI: 10.1002/pon.3539, , , , , , , , , and (
- Issue published online: 13 OCT 2014
- Article first published online: 15 APR 2014
- Manuscript Accepted: 12 MAR 2014
- Manuscript Revised: 22 FEB 2014
- Manuscript Received: 5 OCT 2013
- Natural Science Foundation of China. Grant Numbers: 91232717, 81300944, 31300925, 81372487, 31000503
- National Science and Technology Support Program. Grant Number: 2009BAI77B06
- breast cancer;
- adjuvant chemotherapy;
- cognitive function;
- attention network test
Complaints about attention disorders are common among breast cancer survivors who have undergone chemotherapy treatment. However, it is not known whether these complaints indicate a global attention deficit or the selective impairment of attention networks.
This study sought to investigate the attentional abilities of breast cancer patients after chemotherapy treatment using the attention network test (ANT).
The participants included breast cancer patients who had undergone chemotherapy (CT, N = 58), patients who had not undergone chemotherapy (non-CT, N = 53), and matched healthy controls (HC, N = 55). All participants completed the ANT, which provides measures of three independent attention networks (alerting, orienting, and executive control) and neuropsychological background tests.
Our results indicated that the chemotherapy-treated breast cancer patients had significant deficits in the alerting and executive control networks but not in the orienting network. The CT group scored significantly lower in several cognitive tasks, including attention, memory, and information processing tasks, relative to the other two groups. Additionally, significant correlations were found between information processing and the efficiency of the executive control network within the CT group.
These results suggest that the three attention networks were selectively impaired following chemotherapy treatment, which affected different brain areas in the breast cancer survivors. Copyright © 2014 John Wiley & Sons, Ltd.