The purpose of this study was to test the convergent, discriminant, and clinical validity of the Quality of Life in Childhood Cancer (QOLCC) instrument for measuring the quality of life of Taiwanese children who suffer from cancer. In total, 160 patients were recruited for the study, including 105 male and 55 female. Overall, QOLCC consisted of generic measure and disease-specific domains to assess the Quality of Life (QOL) for children treated for cancer. The QOLCC is a symptom or problem-based questionnaire with the conceptual framework that health-related problems can be solved from both a biomedical perspective (e.g. changing the patient's medical treatment can enhance the QOL) and from a biobehavioral perspective (e.g. problem solving on a daily basis). This QOLCC, which can be administered in 15 min, is the first documented measure of the QOL administered directly to Taiwanese Children. It demonstrates acceptable psychometric properties. Application of the QOLCC to Taiwanese children with cancer produced encouraging results, validation from a larger independent parent population is still necessary. Copyright © 2003 John Wiley & Sons, Ltd.