Decontamination of Prions by the Flowing Afterglow of a Reduced-pressure N2O2 Cold-plasma (pages 612–618)
Benaïssa Elmoualij, Olivier Thellin, Stéphanie Gofflot, Ernst Heinen, Pierre Levif, Jacynthe Séguin, Michel Moisan, Annie Leduc, Jean Barbeau and Willy Zorzi
Article first published online: 11 APR 2012 | DOI: 10.1002/ppap.201100194
Transmissible spongiform encephalopathies, also called prion diseases, represent a family of neurodegenerative disorders. Since the infectious forms of prions are transmissible and highly resistant to decontamination methods, they represent a challenge for science, medicine, and public health/food systems. Suitable decontamination procedures are generally incompatible with the materials from which medical devices are made. We show that the N2O2 discharge afterglow reduces the immunoreactivity of both non-infectious recombinant and pathogenic prion proteins deposited on polystyrene substrates, and achieves significant decontamination of stainless steel sutures inoculated with infectious forms of prions.