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Fabrication of pH-Tunable Calcium Phosphate Nanocapsules via Dendrimer-Templated Assembly for Intracellular Lysosomal Release of Drugs

Authors


  • [+]Present address: Maharashtra Institute of Pharmacy MIT Campus, Paud Road, Pune-411038, India

E-mail: shashwat.banerjee@piramal.com

Abstract

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A pH-responsive dendrimer templated polymer-calcium phosphate core shell nanostructure is developed. Upon exposure to cellular lysosomal pH, a guest anticancer drug is released from the nanocapsule by dissolution of the CaP shell. Such a stimuli responsive carrier enables on-demand controlled release of drugs in acidic organelles.

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