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pH-Responsive Theranostic Polymer-Caged Nanobins: Enhanced Cytotoxicity and T1 MRI Contrast by Her2 Targeting

Authors


E-mail: stn@northwestern.edu

Abstract

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A polymer-caged nanobin (PCN) theranostic platform with a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with herceptin and GdIII-based magnetic resonance imaging (MRI) contrast agents is reported. In vitro testing reveals an 120-fold improvement in cellular GdIII uptake in comparison with clinically approved DOTA-GdIII, leading to significant T1 MRI contrast enhancement.

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