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Keywords:

  • biosensors;
  • colorimetric detection;
  • DNA;
  • graphene oxide;
  • gold nanoparticles
Thumbnail image of graphical abstract

Single-strand DNA-modified Au–nanoparticles (ssDNA–AuNPs) are used to cross-link graphene oxide (GO) and lead to the final formation of a soft complex, while no such precipitation is observed with double-stranded or otherwise well-folded structure-modified AuNPs. Based on this finding, novel red-to-white colorimetric assays that allow simple, sensitive, and selective detection of a broad range of targets including DNA, small biomolecule, metal ions are reported.