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Conjugation of Graphene Oxide with DNA-Modified Gold Nanoparticles to Develop a Novel Colorimetric Sensing Platform




Single-strand DNA-modified Au–nanoparticles (ssDNA–AuNPs) are used to cross-link graphene oxide (GO) and lead to the final formation of a soft complex, while no such precipitation is observed with double-stranded or otherwise well-folded structure-modified AuNPs. Based on this finding, novel red-to-white colorimetric assays that allow simple, sensitive, and selective detection of a broad range of targets including DNA, small biomolecule, metal ions are reported.