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Keywords:

  • nanoparticle hybrids;
  • surface molecular structures;
  • peptides;
  • immune responses;
  • dendritic cells
Thumbnail image of graphical abstract

By tuning the chemical modalities on gold nanoparticle surface using hexapeptide ligands the responses of immune cells (dendritic cells) to nanoparticles can be remarkably manipulated from minimum reaction (in the presence of negatively charged peptide ligands) to activation (in the presence of peptide ligands with aromatic rings containing amino acids).