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Amino Acid Structure Determines the Immune Responses Generated by Peptide–Gold Nanoparticle Hybrids

Authors

  • Hong Yang,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
    2. Division of Infectious & Immunological Diseases, BC Children's Hospital and Child & Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, Canada
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  • Yingzhe Zhou,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
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  • Shan-Yu Fung,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
    2. Division of Infectious & Immunological Diseases, BC Children's Hospital and Child & Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, Canada
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  • Licun Wu,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
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  • Kevin Tsai,

    1. Division of Immunity in Health & Diseases, BC Children's Hospital and Child & Family Research Institute, Department of Pathology, University of British Columbia, Vancouver, Canada
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  • Rusung Tan,

    1. Division of Immunity in Health & Diseases, BC Children's Hospital and Child & Family Research Institute, Department of Pathology, University of British Columbia, Vancouver, Canada
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  • Stuart E. Turvey,

    1. Division of Infectious & Immunological Diseases, BC Children's Hospital and Child & Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, Canada
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  • Tiago Machuca,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
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  • Marc de Perrot,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
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  • Thomas K. Waddell,

    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
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  • Mingyao Liu

    Corresponding author
    1. Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada
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Abstract

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By tuning the chemical modalities on gold nanoparticle surface using hexapeptide ligands the responses of immune cells (dendritic cells) to nanoparticles can be remarkably manipulated from minimum reaction (in the presence of negatively charged peptide ligands) to activation (in the presence of peptide ligands with aromatic rings containing amino acids).

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