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Production of Cationic Nanogels with Potential Use in Controlled Drug Delivery

Authors

  • Aintzane Pikabea,

    1. POLYMAT, Bionanoparticles Group Department of Applied Chemistry, UFI 11/56, Faculty of Chemistry University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain
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  • Jose Ramos,

    1. POLYMAT, Bionanoparticles Group Department of Applied Chemistry, UFI 11/56, Faculty of Chemistry University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain
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  • Jacqueline Forcada

    Corresponding author
    1. POLYMAT, Bionanoparticles Group Department of Applied Chemistry, UFI 11/56, Faculty of Chemistry University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain
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Abstract

Dual-stimuli-responsive nanogel particles based on poly(2-(diethylamino)ethyl) methacrylate (PDEAEMA) cross-linked with ethylene glycol dimethacrylate (EGDMA) are prepared via batch emulsion polymerization. An in-depth study of their swelling behavior is carried out, which presents a dual-dependent thermo- and pH-sensitivity tunable with the ionic strength. The study reveals that nanogel particles undergo a unique transition from a swollen state to a collapsed state at physiological conditions. Such systems presenting tunable sensitivity and synthesized using biocompatible components could be suitable for applications in the field of controlled drug or gene delivery.

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