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Poly(Acrylic Acid)-Capped and Dye-Loaded Graphene Oxide-Mesoporous Silica: A Nano-Sandwich for Two-Photon and Photoacoustic Dual-Mode Imaging

Authors

  • Kim Truc Nguyen,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
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    • These authors contributed equally to this work.

  • Sivaramapanicker Sreejith,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
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    • These authors contributed equally to this work.

  • James Joseph,

    1. Centre for Optical and Laser Engineering (COLE), School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore
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    • These authors contributed equally to this work.

  • Tingchao He,

    1. Division of Physics and Applied Physics, Centre for Disruptive Photonic Technologies (CDPT), School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
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  • Parijat Borah,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
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  • Eng You Guan,

    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
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  • Sun Woh Lye,

    1. Centre for Optical and Laser Engineering (COLE), School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore
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  • Handong Sun,

    1. Division of Physics and Applied Physics, Centre for Disruptive Photonic Technologies (CDPT), School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
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  • Yanli Zhao

    Corresponding author
    1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
    2. School of Materials Science and Engineering, Nanyang Technological University, Singapore
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Abstract

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Growth of mesoporous silica on both sides of graphene oxide affords a nano-sandwich (NS) material. A two-photon active dye is then loaded into the mesopores of the NS followed by sealing with poly(acrylic acid). The obtained hybrid exhibits low cytotoxicity and excellent capability for two-photon and photoacoustic dual-mode bioimaging.

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