Study on the Relationship between Particle Size and Near Infrared Diffuse Reflectance Spectroscopic Data (pages 219–222)
Annamária Szalay, István Antal, Zsolt Zsigmond, Sylvia Marton, István Erős, Géza Regdon jr. and Klára Pintye-Hódi
Version of Record online: 6 DEC 2005 | DOI: 10.1002/ppsc.200500870
Near-infrared diffuse reflectance spectroscopy (NIRDRS) was used to retrieve the mean particle size of compacted powders. Sieved sorbitol was used as a model substance for pharmaceutical products. The effects of the particle characteristics on the spectral changes were described on the basis of the Kubelka-Munk theory, taking the scattering into consideration. It is shown that this technique offers a fast, non-destructive test method that can be applied after elaborate calibration.